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The treadmill is one of the Best Home Exercise Machine that you can purchase online. It allows you to do workout according to your time preference and mindset. You can do a leg workout, walking, jogging, and running with the use of a treadmill at home.

In this article, we are going to describe the 8 Ultimate Benefits of Using Treadmill at Home which you can get as well. You just need to buy the Best Treadmill In India to get fit and strong without going to the gym. Read every detail carefully and then share it on social mediate websites with your friends and family.

Weight Loss

The number one benefit of using a treadmill is that you can maintain your body weight percentage. You can be fit and strong by using a treadmill for up to 30 minutes a day. It will increase your stamina and also helps in weight loss training program. People who are suffering from body shaming and the overweight problem they should buy the treadmill and do exercise on it for up to 30 minutes.

Weight loss becomes a main issue in the fitness industry. Lots of myths are rumoring and people got confused about it. On the other hand, weight loss is a continuous process that you have to follow on regular basis. You just need to maintain your diet as well as weight loss program. Use the treadmill regularly and maintain your diet will show you fast result in weight loss.

Train Legs

Treadmill trains legs and provides a great shape to our thighs. If your thigh has extra weight and you want a tight thigh then you should run on the treadmill daily. Running on the treadmill will tight your thigh and you will get the muscular and tight thigh. You can also lose thigh weight if you have a large or overweight thigh.

Save Time & Money

The Home Treadmill provides you the facility to do exercise & workout at any time. Whenever you are free you can start your exercise on the treadmill which means you don’t have to join the expensive gym that saves money. The Motorised Treadmill comes up with pre-set training programs that help you in an exercise that also saves money because you don’t have to hire the trainer to train yourself. The home treadmill allows you to train yourself according to your timeframe.

Convenient Exercise Machine

Home Treadmill is one of the convenient exercise machines because it comes in a budget-friendly price range and amazing folding design. The folding treadmills are the best home treadmill that you can store under the sofa & bed. You can easily move the treadmill from one place to another without taking anyone’s help.

Easy to Use

The treadmill is easy to use exercise machines compare to other exercise machines. You just need to start the treadmill if it’s a motorized treadmill otherwise manual treadmill doesn’t need to start. Manual Treadmill comes up with just a running belt that moves through your legs. The motorized treadmill consumes electricity and provides great performance.

Improves Blood Circulation

If you will use the treadmill regularly so it will improve your blood circulation and heart rate as well. People who are suffering from health diseases like heart problems, bone pain, muscle pain, etc so you should start running on a treadmill. You will get lots of other health benefits by running on the treadmill on daily basis.

Good for Mental Health

Nowadays, we all know that people are facing mental health issues. Depression becomes the main issue in the young generation for suicide. Running on a treadmill increases your mental health and also decreases the chances of depression. It will provide positivity and improve confidence in human beings. So you should start using a treadmill in your home regularly if you are facing any mental health issue.

Strong Memory

Running regularly makes your memory stronger and you can learn and teach anything so easily. All the students who face learning problem they should use the treadmill and run daily approximately 30 minutes. When we run so our whole body starts exercising that’s why each part of the body becomes stronger.

Conclusion

We have discussed the 8 Ultimate Benefits of Using Treadmill at Home. These are just 8 benefits but there are also other benefits of using the treadmill on daily basis. There are lots of treadmills available in the market that you can purchase for your home use. You should buy the Best Folding Treadmill In India and use it for 30 minutes on daily basis for getting the above benefits.

People who like the article they should share these advances of the treadmill with your friends and colleagues. If you want to get more articles related to Health, Fitness, Lifestyle, Beauty, and Fashion bookmark the website. A team of professionals writes these articles by doing deep research. All the very best for your life!

The latest study by Dr. Sophie Paczesny and others at MUSC Hollings Cancer Center revealed a new class of immune cell biomarkers, which may reveal which patients are most at risk of graft-versus-host disease (GVHD). This study was published on Science Translational Medicine.

Paczesny, director of the Department of Microbiology and Immunology at MUSC, explained: “Allogeneic HSCT remains the only effective therapy for leukemia. In HSCT, donor-matched cells are injected into the blood of diseased patients and eventually enter the bone marrow. Some of these cells differentiate into immune cells that help eliminate residual leukemia cancer cells that are not killed by chemotherapy. However, some donors’ immune cells may attack the patient’s own healthy tissue at the same time, which is called graft-versus-host disease.”

GVHD affects up to 50% of patients undergoing HSCT and can manifest in multiple organs. About one-third of people with GVHD experience localized effects in the gastrointestinal tract (GI-GVHD), posing the highest risk of death.

This phenomenon was further described by Paczesny. “For leukemia patients, the donor cells you provide have different biological or antigenic characteristics than the recipients. This is how these immune cells recognize leukemia and destroy leukemia. However, these antigens are also present in normal tissues especially in body regions with the most microbiota (such as the gut). Therefore, donor immune cells flare up there and symptoms are most difficult to treat.”

Bone marrow stem cells are called pluripotent stem cells, which means that they can mature into many different types of cells. This includes red and white blood cells and other immune cell types responsible for balancing immunity and tolerance, such as dendritic cells and T cells.

Dendritic cells are able to exchange information with T cells through antigen molecules presented by MHC complexes on the cell surface. T cells are activated in recognition of “non-self” antigens and then play a key role in triggering the body’s other defense systems against foreign invaders, which may include transplanted cells from different hosts.

Previous work from the Paczesny laboratory has shown that immune cell signaling pathways in GI-GVHD increase the number of “hyperactivated” pathogenic T cells (Th17 cells) in the blood of these patients. The presence of these aggressive T cells was associated with lower survival compared to patients lacking GVHD or with milder forms of GVHD in the skin. These cells are also unique in their ability to induce ICOS, a class of T cell signaling coreceptors.

Paczesny said. “We are trying to understand where the activation of these T cells comes from. What antigen-presenting cells are?”

Since ICOS ligands are located on the surface of antigen-presenting cells, such as dendritic cells, they can be easily detected using existing technologies, such as flow cytometry, which can scan the blood for external labeling on cells. In this way, individuals who develop GI-GVHD symptoms after treatment may be flagged out.

Paczesny’s group showed that GI-GVHD patients had increased levels of dendritic cells expressing ICOS ligands (specifically a population called plasmacytoid dendritic cells) compared to controls. Crucially, patients with high levels of these cells had a much lower three-year survival compared to low levels of cells.

Dr. Djamilatou Adom, a postdoctoral researcher working with Paczesny, further investigated the role of ICOS signaling using mice in GI-GVHD. First, they showed that genetic abrogation of ICOS ligand production before transplantation of donor mouse bone marrow cells into recipient mice could protect recipient mice from GvHD related death. In addition, the researchers used “humanized” mice with a non-functional immune system and found that transplanting plasmacytoid dendritic cells expressing human ICOS ligands into these mice (whose own bone marrow has been destroyed by radiation) resulted in increased levels of Th17 cells within GVHD.

The involvement of plasmacytoid dendritic cells (pDCs) in GVHD is an interesting finding, Paczesny says. “If these cells are not stimulated, they are generally considered to be tolerogenic. In other words, they can reduce the severity of GVHD. However, if they activate T cells, for example by binding ICOS activation, they become more toxic and may drive the development of GVHD.”